Industry articles

BioSustane SAIB for drug delivery applications:

"The new excipient BioSustane — The interview with Eastman"
Raj Arunagiri
Pharma Excipients, January 2023

In this interview, Raj discussed BioSustane's properties, including how it helps formulate poorly water-soluble APIs.

"Exploring the mucoadhesive behavior of sucrose acetate isobutyrate: a novel excipient for oral delivery of biopharmaceuticals"
Stine Harloff-Helleberg, Lies A. L. Fliervoet, Mathias Fanø, Mechthild Schmitt, Maxim Antopolski, Arto Urtti, Hanne Mørck Nielsen
(2019) Drug Delivery 26:1, 532—541

This article describes the use of sucrose acetate isobutyrate and its mucoadhesive properties for oral delivery of radiolabeled insulin.

"Delivery of radix ophiopogonis polysaccharide via sucrose acetate isobutyrate-based in situ forming systems alone or combined with its mono-PEGylation"
LiNa Wang, Xiao Zheng, Fei Wu, Lan Shen, Xiao Lin,Yi Feng
(2018) Drug Delivery, 25:1, 267—277

This article describes the use of sucrose acetate isobutyrate as an injectable depot for mono-PEGylated radix ophiopogonis polysaccharide, a natural herb fructan found to play a critical role in anti-myocardial ischemia. The sustained delivery lasted for weeks to a month.

"Polymeric and Non-Polymeric Injectable In-Situ Forming Implant Systems for Sustained Delivery of Lornoxicam: In Vitro and In Vivo Evaluation"
Soad Ali Yehia, Sally Adel Abdel Halim, Mary Yosry Aziz
Current Drug Delivery, 2018 March 19

This article describes the use of sucrose acetate isobutyrate as an injectable in situ forming implant (ISI) for sustained delivery of lornoxicam for prolonged pain management.

Cellulose acetate nanofibers for drug delivery:

"Electrospun triaxial nanofibers with middle blank cellulose acetate layers for accurate dual-stage drug release"
YaoyaoYang1, ShuyueChang1, YingfuBai Yutong, DuDeng-GuangYu
Carbohydrate Polymers Volume 243, 1 September 2020, 116477

"A review on the properties of electrospun cellulose acetate and its application in drug delivery systems: A new perspective"
Mohammed AhmadWsoo, ShafinazShahira, Siti Pauliena, Mohd Boharia, Nadirul Hasraf Mat Nayan, Saiful Izwan Abd Razak
Carbohydrate Research Volume 491, May 2020, 107978

"Synthesis of cellulose acetate nanofibers and its application in the release of some drugs"
Fatemeh Mehrabi; Tayebeh Shamspur; Ali Mostafavi; Asma Saljooqi; Fariba Fathirad, Shahid Bahonar
Nanomed Res J, 2(3):199—207, Summer 2017

This article describes use of electrospun cellulose acetate (39.7 wt% acetyl) nanofibers containing acetaminophen or morphine for tableted drug delivery applications.

"Nanosized sustained-release drug depots fabricated using modified triaxial electrospinning"
Guang-Zhi Yang, Jiao-Jiao Li, Deng-Guang Yu, Mei-Feng He, Jun-He Yang, Gareth R. Williams
Acta Biomaterialia, Volume 53, 15 April 2017, Pages 233—241

Using cellulose acetate (CA) as a filament-forming polymeric matrix and ferulic acid (FA) as a model drug, nanoscale drug depots in the form of core-shell fibers were designed and fabricated using a modified triaxial electrospinning process. Note: exact cellulose acetate not specified.

"Three-dimensional electrospun micropatterned cellulose acetate nanofiber surfaces with tunable wettability"
Kakunuri, M., Wanasekara, N. D., Sharma, C. S., Khandelwal, M., Eichhorn S. J.
J. Appl. Polym. Sci., 134, 44709, 2017

This article describes preparation of three-dimensional polymer nanofibrous mats of cellulose acetate with tunable wettability by an electrospinning process. These mats are viewed as having utility for drug delivery and tissue scaffolding applications. Note: exact cellulose acetate not specified.

Cellulose acetate phthalate (C-A-P) drug delivery applications:

"Design and Evaluation of pH-Dependent Nanosystems Based on Cellulose Acetate Phthalate, Nanoparticles Loaded with Chlorhexidine for Periodontal Treatment"
Gustavo Vidal-Romero, María L. Zambrano-Zaragoza, Lizbeth Martínez-Acevedo, Gerardo Leyva-Gómez, Susana E. Mendoza-Elvira and David Quintanar-Guerrero
Pharmaceutics 2019, 11, 604; doi:10.3390/pharmaceutics11110604

"Sequential release of multiple drugs from flexible drug delivery films"
Cheryl L. Jennings, Ellis K. Perry, Thomas D. Dziubla, David A. Puleo
International Journal of Polymeric Materials and Polymeric Biomaterials, Volume 66, 2017-Issue 11

This article describes use of layered film devices comprising cellulose acetate phthalate (C-A-P) and Pluronic F-127 for achieving sequential drug delivery release profiles.

"Optimization of Chitosan and Cellulose Acetate Phthalate Controlled Delivery of Methylprednisolone for Treatment of Inflammatory Bowel Disease"
Swati Jagdale, Apoorva Chandekar
Advanced Pharmaceutical Bulletin [30 Jun 2017, 7(2):203—213]

This article describes use of cellulose acetate phthalate (C-A-P) and chitosan mixtures for colonic delivery of methylprednisolone (anti-inflammatory steroid) to treat inflammatory bowel disease (IBD).

"Cellulose Acetate Phthalate and Antiretroviral Nanoparticle Fabrications for HIV Pre-Exposure Prophylaxis"
Subhra Mandal, Karl Khandalavala, Rachel Pham, Patrick Bruck, Marisa Varghese, Andrew Kochvar, Ashley Monaco, Pavan Kumar Prathipati, Christopher Destache, and Annemarie Shibata
Polymers 2017, 9(9), 423

This article describes preparation and utility of nanoparticles of cellulose acetate phthalate (C-A-P) and dolutegravir (an integrase strand transfer inhibitor with potent antiretroviral activity) for use in HIV prophylaxis applications.

"Generation of quercetin/cellulose acetate phthalate systems for delivery by supercritical anti-solvent process"
García-Casas, Montes A, Pereyra C, Martínez de la Ossa EJ
Eur J Pharm Sci. 2017 Mar 30;100:79—86

This article describes preparation of co-precipitated nanoparticles of quercetin and cellulose acetate phthalate (C-A-P) using a supercritical anti-solvent process that could benefit pharmaceutical, cosmetics, or nutraceutical applications.

CAB (cellulose acetate butyrate) for drug delivery applications:

"Miscibility and sustained release of drug from cellulose acetate butyrate/caffeine films"
Laíse M.Furtado, Karina C.P.Hilamatu, Krishnasamy Balaji, Rômulo A. Ando, Denise F.S.Petria
Journal of Drug Delivery Science and Technology, Volume 55, February 2020, 101472

"Electrospun cellulose acetate butyrate/polyethylene glycol (CAB/PEG) composite nanofibers: A potential scaffold for tissue engineering"
Hui-LiTana, DanKaib, PooriaPasbakhsh, Sin-YeangTeowe, Yau-YanLima, Janarthanan Pushpamalar
Colloids and Surfaces B: Biointerfaces, Volume 188, April 2020, 110713

"Cellulose acetate butyrate bilayer coated microspheres for controlled release of ciprofloxacin"
Keerti V. Phadke, Lata S. Manjeshwar, Tejraj M. Aminabhavi, M. P. Sathisha
Polymer Bulletin, Issue 3/2018

This article describes use of cellulose acetate butyrate-coated gelatin microspheres for sustained delivery of ciprofloxacin.
Note: exact cellulose acetate butyrate not specified.

"Design and optimization of gastro-retentive microballoons for enhanced bioavailability of cinnarizine"
Hussein O. Ammar, Mahmoud Ghorab, Rabab Kamel, Alaa H. Salama
Drug Delivery and Translational Research, June 2016, Volume 6, Issue 3, pp 210–224

This article describes a gastro-retentive drug delivery system consisting of microballoons prepared from CAB 381-20 and containing cinnarizine.

Cellulose acetate for drug delivery applications:

"Electrospun progesterone‐loaded cellulose acetate nanofibers and their drug sustained‐release profiles"
Gabriella Onila do Nascimento Soares, Raíssa Ribeiro Lima Machado, Mariana Mendonça Diniz, Aline Bruna da Silva
Polymer Engineering and Science, Volume60, Issue12, December 2020, Pages 3231-3243

"Blend of cellulose ester and enteric polymers for delayed and enteric coating of core tablets of hydrophilic and hydrophobic drugs"
Sogra F. Barakh Ali, Hamideh Afrooz, Rachel Hampel, Eman M. Mohamed, Raktima Bhattacharya, Phillip Cook, Mansoor A. Khan, Ziyaur Rahman
Int J Pharm. 2019 Aug 15;567:118462. doi: 10.1016/j.ijpharm.2019.118462. Epub 2019 Jun 24

"Development of a Multivariate Predictive Dissolution Model for Tablets Coated with Cellulose Ester Blends"
Eman M. Mohamed, Tahir Khuroo, Hamideh Afrooz, Sathish Dharani, Khaldia Sediri, Phillip Cook, Rajendran Arunagiri, Mansoor A. Khan, and Ziyaur Rahman
Pharmaceuticals 13(10):311, October 2020

"Cellulose Acetate Based Material with Antibacterial Properties Created by Supercritical Solvent Impregnation"
Stoja Milovanovic, Tijana Adamovic, Ksenija Aksentijevic, Dusan Misic, Jasna Ivanovic, and Irena Zizovic
International Journal of Polymer Science, Volume 2017 (2017), Article ID 8762649, 9 pages

This article describes supercritical solvent impregnation of cellulose acetate beads (Eastman CA 320S, 32% acetyl) with antimicrobial carvacrol (6.0–33.6 wt%).

"Dry powder coated osmotic drug delivery system"
Yang Q, Ma Y, Zhu J
Eur J Pharm Sci., 2018 Jan 1;111:383—392

This article describes unique powder coating technology using Eastman CA 398-10 NF/EP to prepare a dry powder-coated osmotic drug delivery system.